{"id":1523,"date":"2025-02-22T14:58:58","date_gmt":"2025-02-22T12:58:58","guid":{"rendered":"https:\/\/www.technology-asgard.com\/?p=1523"},"modified":"2025-02-26T21:04:40","modified_gmt":"2025-02-26T19:04:40","slug":"project-sd-sukhachevs-solution-against-stomach-diseases","status":"publish","type":"post","link":"https:\/\/www.technology-asgard.com\/en\/project-sd-sukhachevs-solution-against-stomach-diseases\/","title":{"rendered":"Project SD &#8211; Sukhachev&#8217;s solution against stomach diseases"},"content":{"rendered":"\n<p><strong>Project SD &#8211; Sukhachev&#8217;s solution against stomach diseases<\/strong><br><br><br>This is a work, and the author&#8217;s right to a work under international law comes into force from the moment the work is created.<\/p>\n\n\n\n<p><strong>Author &#8211; Sukhachev Denis Pavlovich<\/strong><\/p>\n\n\n\n<p><strong>The optimal composition of the solution for fighting <em>Escherichia coli <\/em>in the stomach with the addition of glycerin and 3% alcohol<\/strong><\/p>\n\n\n\n<p><strong>Objective:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong><em>Eradication<\/em><\/strong><strong> of <em>E. coli <\/em>in the stomach<\/strong><\/li>\n\n\n\n<li><strong>Reducing mucosal irritation<\/strong><\/li>\n\n\n\n<li><strong>Increase the bioavailability of active ingredients<\/strong><\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong>1. Solution components<\/strong><\/p>\n\n\n\n<p>\u2705<strong> Methylene blue-OH (MB-OH, 0.1-0.5%)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Antibacterial effect: destroys the respiratory chain of <em>E. coli<\/em>.<\/li>\n\n\n\n<li>Penetrates bacterial biofilms.<\/li>\n\n\n\n<li>Photosensitizer for possible PDT.<\/li>\n<\/ul>\n\n\n\n<p>\u2705<strong> Genzian violet (Crystal Violet, 0.05-0.1%)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Additional bactericidal effect.<\/li>\n\n\n\n<li>Kills gram-negative bacteria.<\/li>\n\n\n\n<li>Disrupts the DNA of bacteria.<\/li>\n<\/ul>\n\n\n\n<p>\u2705<strong> Curcumin (0.2-0.5%)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>A natural antibacterial agent.<\/li>\n\n\n\n<li>Antioxidant, helps to heal the mucosa.<\/li>\n\n\n\n<li>It works better with ethanol.<\/li>\n<\/ul>\n\n\n\n<p>\u2705<strong> Eosin Y (0.05-0.1%)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Helps to destroy bacterial membranes.<\/li>\n\n\n\n<li>Fluorescent marker (can be used in research).<\/li>\n<\/ul>\n\n\n\n<p>\u2705<strong> Glycerin (10-15%)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Protects the mucous membrane.<\/li>\n\n\n\n<li>Improves the solubility and stability of MB-OH and curcumin.<\/li>\n\n\n\n<li>Extends the contact of the solution with bacteria.<\/li>\n<\/ul>\n\n\n\n<p>\u2705<strong> 3% alcohol solution (C\u2082H\u2085OH, balance up to 100%)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Increases the permeability of MB-OH and Genzianviolet.<\/li>\n\n\n\n<li>Destroys bacterial biofilms.<\/li>\n\n\n\n<li>Improves the absorption of curcumin.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong>2. Properties of the resulting solution<\/strong><\/p>\n\n\n\n<p>\ud83d\udccc<strong> Antibacterial activity <\/strong>&#8211; the combined effect of MB-OH, Genzianviolet and curcumin.<br>\ud83d\udccc<strong> Penetration through biofilms <\/strong>&#8211; ethanol and Eosin Y help to destroy the defense of bacteria.<br>\ud83d\udccc<strong> Mucosal protection <\/strong>&#8211; glycerin minimizes irritation.<br>\ud83d\udccc<strong> Increased stability <\/strong>&#8211; thanks to the alcohol solution and glycerin.<br>\ud83d\udccc<strong> Can be used in photodynamic therapy (PDT) <\/strong>&#8211; activated by light at 660-700 nm.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong>3. Conclusions<\/strong><\/p>\n\n\n\n<p>\u2705<strong> The resulting solution is optimal for fighting <em>E. coli <\/em>in the stomach.<\/strong><br>\u2705<strong> The combination of antimicrobial dyes, alcohol and glycerin allows for effective penetration of bacterial colonies and biofilms.<\/strong><br>\u2705<strong> The solution can be used as a stand-alone agent or in combination with PDT.<\/strong><br>\u2705<strong> It can be used for efficacy studies in the laboratory.<\/strong><\/p>\n\n\n\n<p>\ud83d\udca1<strong> If you need to calculate the exact concentrations for an experiment or test stability, I can help. What do you think?<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Project SD &#8211; Sukhachev&#8217;s solution against stomach diseases This is a work, and the author&#8217;s right to a work under international law comes into force from the moment the work is created. Author &#8211; Sukhachev Denis Pavlovich The optimal composition of the solution for fighting Escherichia coli in the stomach with the addition of glycerin and 3% alcohol Objective: 1. Solution components \u2705 Methylene blue-OH (MB-OH, 0.1-0.5%) \u2705 Genzian violet (Crystal Violet, 0.05-0.1%) \u2705 Curcumin (0.2-0.5%) \u2705 Eosin Y (0.05-0.1%) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[26],"tags":[],"class_list":["post-1523","post","type-post","status-publish","format-standard","hentry","category-medical-research"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Project SD - Sukhachev&#039;s solution against stomach diseases - Asgard Technology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.technology-asgard.com\/en\/project-sd-sukhachevs-solution-against-stomach-diseases\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Project SD - Sukhachev&#039;s solution against stomach diseases - Asgard Technology\" \/>\n<meta property=\"og:description\" content=\"Project SD &#8211; Sukhachev&#8217;s solution against stomach diseases This is a work, and the author&#8217;s right to a work under international law comes into force from the moment the work is created. 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